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< Back Growth Arrest & Bar Formation growth-arrest-bar-formation Previous Next

Surgical Guide Total Hip Arthroplasty Introduction Bu bir paragraf. Bu metni değiştirmek veya düzenlemek için tıklayın. Çok kolay. Total Hip Arthroplasty Introduction Bu bir paragraf. Bu metni değiştirmek veya düzenlemek için tıklayın. Çok kolay. Total Hip Arthroplasty Introduction Bu bir paragraf. Bu metni değiştirmek veya düzenlemek için tıklayın. Çok kolay. Surgical Guide

< Back Dr. Korhan OZKAN Professor, M.D. Acıbadem Healthcare Group, Orthopaedics and Traumatology – Orthopaedic Oncology Location: Istanbul, Türkiye Education and Training 2013 – Medical University of Vienna , Orthopaedic Oncology Center, Austria 2012 – Royal Orthopaedic Hospital , Birmingham, United Kingdom 2011 – Universitätsklinikum Münster , Orthopaedic Oncology Center (Prof. Dr. Georg Gosheger), Germany 2005 – Istanbul University, Istanbul Faculty of Medicine , Department of Orthopaedics and Traumatology 2005 – Allgemeines und Orthopaedisches Landeskrankenhaus Stolzalpe (Prof. Reinhard Graf), Austria 2000 – Marmara University Faculty of Medicine , Istanbul, Türkiye Professional Experience 2023 – Present – Acıbadem Healthcare Group , Department of Orthopaedics and Traumatology 2006 – 2023 – Istanbul Medeniyet University, Göztepe Training and Research Hospital , Department of Orthopaedics and Traumatology 2006 – Zeynep Kamil Training and Research Hospital , Orthopaedic Surgeon 2006 – İznik State Hospital , Orthopaedic Surgeon 2005 – 2006 – Florence Nightingale Hospital , Department of Orthopaedics and Traumatology 2000 – 2005 – Istanbul University, Istanbul Faculty of Medicine , Research Assistant, Department of Orthopaedics and Traumatology https://www.ortopediktumor.com/ https://www.acibadem.com.tr/doktor/korhan-ozkan/ Oncologic Orthopaedics korhanozkan76@gmail.com Previous Next

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< Back Non-Ossifying Fibroma (NOF) Non-ossifying fibroma (NOF) is a benign, non-osteogenic bone lesion composed of fibroblastic cells, typically located in the metaphysis of long bones during childhood and adolescence. It is usually asymptomatic and detected incidentally on radiographs obtained for other reasons. 1.Synonyms Fibrous cortical defect (for smaller lesions) Metaphyseal fibrous defect Fibroxanthoma Nonosteogenic fibroma Fibrous histiocytoma of bone Sometimes confused with “cortical desmoid” (different localization) 2. Associated Conditions / Syndromes NOF can be an isolated finding but may also be associated with certain systemic syndromes: Neurofibromatosis type 1 (NF1) Jaffe-Campanacci syndrome: Multiple NOFs + café-au-lait macules + mental retardation + hypogonadism + cardiac anomalies 3. Epidemiology Age: Common between 5–20 years Sex: Slight male predominance (~1.6:1) Prevalence: Seen radiographically in 30–40% of children Most frequent locations: Distal femur, proximal tibia, distal tibia, proximal fibula 4. Pathogenesis and Genetics Previously thought to be a reactive process; current DNA analyses have revealed KRAS , FGFR1 , and NF1 mutations → suggesting a neoplastic process related to RAS-MAPK pathway activation. Typically eccentric in location, adjacent to the cortex. 5. Clinical Features Usually asymptomatic Large lesions : Mechanical weakness → risk of pathological fracture May cause pain Diagnosis is often facilitated if a pathological fracture is present 6. Imaging Radiograph : Eccentric, metaphyseal, cortically based, well-defined, lobulated radiolucent lesion with internal septations Often 1–3 cm (fibrous cortical defect) or larger (NOF) CT : Demonstrates cortical thinning and intracortical location MRI : Hyperintense on T2; hypointense on T1 if hemosiderin present Periosteal reaction is typically absent 7. Histology Gross : Well-circumscribed, soft, yellow-brown fibrous tissue Cut surface may show small foci of hemorrhage and hemosiderin deposits Microscopic : Well-vascularized fibrous stroma with haphazardly arranged spindle-shaped fibroblasts Interspersed lipid-laden foam cells (xanthomatous histiocytes) Focal multinucleated giant cells Frequent hemosiderin pigment deposition Minimal cellular atypia, rare mitotic figures Occasional ossification or bone trabeculae within fibrous stroma Sclerotic bony rim may be present at the periphery Differential Diagnosis : Aneurysmal bone cyst, fibrous dysplasia, giant cell tumor 8. Treatment and Natural History Small/asymptomatic : Observation (most regress and sclerose spontaneously by late adolescence) Large/high fracture risk : Curettage + bone grafting Prophylactic fixation may be considered Recurrence after surgery is rare NOF at proximal tibia (lateral view) NOF at proximal tibia (AP view) Radiograph and coronal MRI of the proximal tibia show an eccentric, multilobulated cortically based lucent lesion with a thin sclerotic rim and no periosteal reaction. On MRI, the lesion demonstrates low T1 and heterogeneously high T2 signal intensity with a low-signal peripheral rim. Findings are consistent with a non-ossifying fibroma. Previous Next

< Back Humeral Osteotomies humeral-osteotomies Previous Next

< Back Dr. Erhan OKAY Oncologic Orthopaedics erhanokay@yahoo.com Previous Next

< Back Deformity Analysis deformity-analysis Previous Next

< Back Dr. Savas CAMUR University of Health Sciences, Istanbul, Umraniye Research and Education Hospital https://www.savascamur.com/ Hip & Knee Arthroplasty / Trauma savascamur@gmail.com Previous Next

< Back Dr. Batuhan AYHAN Oncologic Orthopaedics Previous Next